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Apart From the receptors Ffar2 and Ffar3 that we discussed above, AMP-activated protein kinase (AMPK) performs an essential role in this regulation, as summarized in Fig. The internet result’s a reduction of the concentrations of free fatty acids in plasma (114) and a decrease in physique weight (17, 121–124). SCFAs regulate the stability between fatty acid synthesis, fatty acid oxidation, and lipolysis in the physique. Ffar3 has a extra widespread expression pattern than Ffar2, with the highest expression in adipose tissue. The highest mRNA expression of Ffar2 was present in immune cells such as monocytes, B-lymphocytes, and polymorphonuclear cells (109–111).
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